Epinephrine is the adrenal medulla’s principal hormone — ~80% of adrenal catecholamine output. It is synthesized from norepinephrine via the enzyme PNMT, which is upregulated by cortisol arriving through intra-adrenal portal vessels
Epinephrine, commonly known by its trade name Adrenaline, is an endogenous catecholamine and one of the most potent, rapid-acting, and essential drugs in the anesthesiologist’s arsenal.