Atracurium is an intermediate-acting, non-depolarizing neuromuscular blocker. Hofmann elimination (independent of renal/hepatic function). Causes histamine release (risk of hypotension/tachycardia). Dose: 0.4-0.5 mg/kg IV. Reversed by neostigmine/glycopyrrolate. Ideal for patients with organ dysfunction.
Midazolam is a short-acting benzodiazepine used for preoperative sedation, anxiolysis, and amnesia. Rapid IV onset (1-2 min), metabolized hepatically. Causes respiratory depression; requires reversal with flumazenil. Synergistic with opioids. Key for procedural sedation and anxiolysis in anesthesia.
It is an enantiomer of medetomidine. It acts as an alpha2 agonist although it has mild actions on alpha 1 receptors also. The ratio of 2 to receptor selectivity