Milrinone

Milrinone mechanism infographic: PDE-3 inhibitor increases cAMP, producing positive inotropy and arterial vasodilation (↓SVR, ↓PVR). Key uses: RV failure, post-cardiac surgery low CO, β-blocked patients. Warning: renal adjustment required, avoid bolus if hypotensive.

Milrinone is a PDE-3 inhibitor used in cardiac anesthesia as an inodilator—it increases contractility while reducing afterload and pulmonary vascular resistance. Ideal for right ventricular failure and β-blocked patients. Key risks: hypotension and prolonged half-life in renal failure. Avoid bolus if hypotensive or hypovolemic.

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